LYMPHOID NEOPLASIA ASK1 promotes apoptosis of normal and malignant plasma cells
نویسندگان
چکیده
1Genomics Research Center, Academia Sinica, Taipei, Taiwan; 2Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan; 3Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; 4Institute and Department of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan; and 5Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
منابع مشابه
ASK1 promotes apoptosis of normal and malignant plasma cells.
Although the overproduction of immunoglobulins by short-lived plasma cells accompanying an immune response links with their apoptosis, how long-lived plasma cells adapt to ensure their longevity in this context is obscure. Here, we show that apoptosis signal-regulating kinase 1 (ASK1) contributes to apoptosis of plasma cells because ASK1 activity was induced during differentiation of short-live...
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تاریخ انتشار 2012